Supporting Research

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Supporting Research

Explore the Latest Research and Findings Related to REMplenish, Myofunctional Therapy, Snoring, and Sleep Apnea.

Mayo Clinic REMplenish Trial

Mayo Clinic is starting a clinical trial on REMplenish for patients with mild-moderate obstructive sleep apnea and snoring. This research study is being done to determine whether the repetition and resistance from the daily use of the REMplenish myofunctional therapy nozzle will improve obstructive sleep apnea and primary snoring in participants.

View clinical trial →

REMplenish Usability Study

Our initial 2020 usability study found that after one month of using REMplenish, users' overall satisfaction with the product was 80%; 93% reported subjective improvements in reducing snoring intensity, occurrence, and/or impact; and 34% of participants reported improvements in tiredness. Bedpartner-reported median snoring intensity decreased from somewhat loud to soft or quiet, overall snoring occurrence decreased, and median snoring impact reduced.

Related Research

Read the research that REMplenish's development was based on.

Didgeridoo playing as alternative treatment for obstructive sleep apnoea syndrome: randomised controlled trial

Puhan MA, Suarez A, Lo Cascio C, Zahn A, Heitz M, Braendli O.

Effects of oropharyngeal exercises on patients with moderate obstructive sleep apnea syndrome

Guimarães KC, Drager LF, Genta PR, Marcondes BF, Lorenzi-Filho G.

Effects of Oropharyngeal Exercises on Snoring: A Randomized Trial

Ieto V, Kayamori F, Montes MI, Hirata RP, Gregório MG et al.

Myofunctional Therapy to Treat Obstructive Sleep Apnea: A Systematic Review and Meta-analysis

Camacho M, Certal V, Abdullatif J et al.

Oropharyngeal and tongue exercises (myofunctional therapy) for snoring: a systematic review and meta-analysis

Camacho M, Guilleminault C, Wei J.M. et al.

Effect of myofunctional therapy on children with obstructive sleep apnea: a meta-analysis

Bandyopadhyay A, Kaneshiro K, Camacho M.

The Relationship between Depressive Symptoms and Obstructive Sleep Apnea in Pediatric Populations: A Meta-Analysis

Elif Yilmaz, Karim Sedky, David S Bennett

Health-related quality of life and depressive symptoms in children with suspected sleep-disordered breathing

Valerie McLaughlin Crabtree, James W Varni, David Gozal

Inattention, hyperactivity, and symptoms of sleep-disordered breathing

Ronald D Chervin, Kristen Hedger Archbold, James E Dillon, Parviz Panahi, Kenneth J Pituch, Ronald E Dahl, Christian Guilleminault

Can myofunctional therapy increase tongue tone and reduce symptoms in children with sleep-disordered breathing?

Maria Pia Villa, Melania Evangelisti, Susy Martella, Mario Barreto, Marco Del Pozzo

Sleep-Disordered Breathing and Its Association with Nocturnal Enuresis [Bedwetting] at the Primary Schools in Saudi Arabia: A Cross-Sectional Study

Ali Abdullah Alshehri, Mohamed Soliman Hassan Zaki, Sameh Osama Nour, Wala H Gadi, Basem A Zogel, Samar M Alfaifi, Enas M Masmali, Amani B Aburasain, Mohamed Osama Nour

Alterations of brain gray matter volume in children with obstructive sleep apnea

Chenyi Yu, Yuchuan Fu, Yi Lu, Yinyin Huang, Fangfang Chen, Jiayun Wei, Lingling Li, Janet Akoto Ampadu, Yu Wang, Weikun Zheng, Changcan Jiang, Weiyuan Li, Su Lui, Xiaohong Cai

Sleep-Related Breathing Disorders in Children—Red Flags in Pediatric Care

Sigalit Blumer, Ilana Eli, Shani Kaminsky-Kurtz, Yarden Shreiber-Fridman, Eran Dolev, Alona Emodi-Perlman

Neurology of Sleep and Sleep-Related Breathing Disorders and their relationships to Sleep Bruxism

Jerald H. Simmons, MD

Sleep Disordered Breathing and Depression among U.S. Adults: National Health and Nutrition Examination Survey, 2005-2008

Anne G. Wheaton, PhD, Geraldine S. Perry, DrPH, Daniel P. Chapman, PhD, and Janet B. Croft, PhD

Sleep apnea, psychopathology, and mental health care

Christopher N. Kaufmann, PhD, MHS, Ryoko Susukida, PhD, and Colin A. Depp, PhD