Supporting Research

Explore the latest research and findings related to REMplenish, myofunctional therapy, snoring, and sleep apnea.

  • MAYO CLINIC REMPLENISH TRIAL

    Mayo Clinic is starting a clinical trial on REMplenish for patients with mild-moderate obstructive sleep apnea and snoring. This research study is being done to determine whether the repetition and resistance from the daily use of the REMplenish myofunctional therapy nozzle will improve obstructive sleep apnea and primary snoring.

    View clinical trial 

  • REMPLENISH USABILITY STUDY

    Our initial 2020 usability study found that after one month of using REMplenish, users' overall satisfaction with the product was 80%; 93% reported subjective improvements in reducing snoring intensity, occurrence, and/or impact; and 34% of participants reported improvements in tiredness. Bedpartner reported median snoring intensity decreased from somewhat loud to soft or quiet, overall snoring occurrence decreased, and median snoring impact reduced.

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OTHER STUDIES

Didgeridoo playing as alternative treatment for obstructive sleep apnoea syndrome: randomised controlled trial

Puhan MA, Suarez A, Lo Cascio C, Zahn A, Heitz M, Braendli O. Didgeridoo playing as alternative treatment for obstructive sleep apnoea syndrome: randomised controlled trial. BMJ. 2006;332(7536):266-270. doi:10.1136/bmj.38705.470590.55

Effects of oropharyngeal exercises on patients with moderate obstructive sleep apnea syndrome

Guimarães KC, Drager LF, Genta PR, Marcondes BF, Lorenzi-Filho G. Effects of oropharyngeal exercises on patients with moderate obstructive sleep apnea syndrome. Am J Respir Crit Care Med. 2009;179(10):962-966.

Effects of Oropharyngeal Exercises on Snoring: A Randomized Trial

Ieto V, Kayamori F, Montes MI, Hirata RP, Gregório MG et al. Effects of Oropharyngeal Exercises on Snoring: A Randomized Trial. Chest. 2015;148(3):683-691.

Myofunctional Therapy to Treat Obstructive Sleep Apnea: A Systematic Review and Meta-analysis

Camacho M, Certal V, Abdullatif J et al. Myofunctional Therapy to Treat Obstructive Sleep Apnea: A Systematic Review and Meta-analysis. Sleep. 2015;38(5):669-675.

Oropharyngeal and tongue exercises (myofunctional therapy) for snoring: a systematic review and meta-analysis

Camacho M, Guilleminault C, Wei J.M. et al. Oropharyngeal and tongue exercises (myofunctional therapy) for snoring: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol. 2018;275(4):849-855.

Effect of myofunctional therapy on children with obstructive sleep apnea: a meta-analysis

Bandyopadhyay A, Kaneshiro K, Camacho M. Effect of myofunctional therapy on children with obstructive sleep apnea: a meta-analysis. Sleep Med. 2020;75:210-217. doi:10.1016/j.sleep.2020.08.003

Upper Airway Collapsibility (Pcrit) and Pharyngeal Dilator Muscle Activity are Sleep Stage Dependent

Carberry JC, Jordan AS, White DP, Wellman A, Eckert DJ. Upper Airway Collapsibility (Pcrit) and Pharyngeal Dilator Muscle Activity are Sleep Stage Dependent. Sleep. 2016;39(3):511-521. Published 2016 Mar 1. doi:10.5665/sleep.5516

Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets

Eckert DJ, White DP, Jordan AS, Malhotra A, Wellman A. Defining Phenotypic Causes of Obstructive Sleep Apnea. Identification of Novel Therapeutic Targets. Am J Respir Crit Care Med. 2013;188(8):996-1004.